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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers (24, 25)

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This mechanistic overlap raises theoretical questions about additive benefit, though emerging evidence suggests that exogenous GLP-1 agonists can produce additional weight loss even in the altered post-surgical gut hormone environment