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Kovacs, GG, Budka, H

222 Microautophagy is the simplest pathway in which cytoplasmic substrates enter vesicles formed by morphological changes in lysosomal or endosomal membranes, and are ultimately degraded within the lysosome

This serves to minimize damage to the rest of the body and enhance treatment outcomes

Interestingly, enhanced protein stability at low pH as a strategy to avoid acid induced unfolding has also been observed in many proteins including cytokines, interleukin-2 (IL-2) and granulocyte colony stimulating factor (G-CSF), which usually get internalised in acidic endosomal compartments, and capsid proteins which ensure viruss survival in acidic intestinal tract 18,19,20

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