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Transcriptional profiling reveals that both the mito-nuclear retrograde (MNR) and the Pap1-dependent oxidative stress response pathways are induced in these mutants, resulting in the upregulation of genes encoding antioxidants, membrane transporters, and thereby increased efflux

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Tumors were measured three times per week until the tumor volumes reached 1500 mm 3

Thus, macrophage polarization in diabetes and its complications is regulated through multidimensional mechanisms and targeting polarization states along with metabolic reprogramming offers promising therapeutic strategies

[Google Scholar] Pourramezan, Z., Oloomi, M., & Kasra-Kermanshahi, R