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Description
Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients
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However, reminiscent of astrocytes of the CNS, EGCs also undergo phenotypic alterations in response to persistent hyperinflammatory insults, inter alia an upregulation of glial fibrillary acidic protein (GFAP) [255] and may contribute to the influx of microbial infection by reducing their release of beneficial factors that enhance gut barrier function, such as 15-hydroxyeicosatetraenoic (15-HETE) [256] and S-nitrosogluthathione (GSNO) [257]
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