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Another form of XO is xanthine dehydrogenase (XD)

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Elevated pO 2 in the alveoli drive an increase in dissolved O 2 concentrations in blood, and this is rapidly communicated to all internal organs where it can cause oxidative damage and disrupt cell signaling processes

Drawing upon prior discussions on the relationship between OA and ferroptosis, blocking or slowing ferroptosis holds promise for protecting cartilage, reducing synovitis, and improving joint function