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These participants were diagnosed with MDD, without psychotic symptoms, according to the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) 104 , which was the version in use at the beginning of this study and was verified by clinical interview with a board-certified psychiatrist

Finally, mechanisms responsible for SCOPAs pleiotropic actions remain only partially explored

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Dosage decisions should be made in consultation with qualified research oversight, and human application requires appropriate institutional review

Exercise increases plasma tryptophan availability, facilitating its transport into the brain, where it is converted into serotonin and increasing the activity of TPH, the rate-limiting enzyme in serotonin synthesis [245]