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Noteworthy is that prior to the trial 85% of the patients regularly performed airway clearance techniques, which means that the daily use of a saline solution may offer additional benefits.21 Even though there is some evidence favoring HS, it seems that both hypertonic and isotonic saline are beneficial in non-CF BE.19,21,21 These results agree with another randomized placebo-controlled study that evaluated the clinical utility of long-term humidification therapy in 108 patients with COPD (n=63) or BE (n=45)

10.1055/s-0043-121143 153 YaribeygiH.ButlerA

keep the reconstituted solution refrigerated and use it within a few weeks

Nutlin-3 acts as a DNA methyltransferase inhibitor to sensitize esophageal cancer to chemoradiation

Molecules 25 , 4649 (2020)