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Even if the compound enters the target tissue/organ, it may not reach the active sites of oxidative damage (e.g., mitochondria)

Shatsky[23], who examined evidence derived from the use of oral and intramuscular administration, indicated that high dose oral administration appeared to be safe, effective and cost-effective, although long term clinical trials were required to confirm this

Morgan AS, Sanderson PE, Borch RF, Tew KD, Niitsu Y, Takayama T et al

Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes

At the end of the trial, the kids who consumed NAC had a reduction in irritability scores by 80% with minimal side effects