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Int J Mol Sci (2021) 22(14):7688

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Synaptic plasticity/long-term potentiation in the hippocampus Mice were anesthetized with isoflurane and brains were quickly transferred to an ice-cold solution (254 mM sucrose, 3 mM KCl, 2 mM MgCl 2 , 2 mM CaCl 2 , 1.25 mM NaH 2 PO 4 , 10 mM D-glucose, and 24 mM NaHCO 3 )

GABA is an inhibitory neurotransmitter that relies on vitamin B6 as a cofactor for biosynthesis.[ref] Related article: GABA: Genetics, Anxiety, and Immune Response Genetic mutations in the PDXK gene, which converts pyridoxine from food into the active P5P form, can cause peripheral polyneuropathy.[ref] Thus, a safer option for someone with peripheral neuropathy may be to supplement with the active P5P form of vitamin B6

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