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Because no single buffer system can effectively maintain a constant pH value over the physiological range of approximately 5 to 7.4, biochemical systems use a set of buffers with overlapping ranges

[DOI] [PubMed] [Google Scholar] 60

Herrmann JR, Turner JR

This usually happens because blood flow increases in the area where the peptide is applied or injected

Such an error coin is worth as much as $50 in circulated condition and could be worth more if you are lucky to find an uncirculated example
