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LTB4 is a lipid mediator derived from arachidonic acid by the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) to stimulate leucocyte functions such as cytokines, chemokinesis, lysosomal enzyme release, superoxide anion production, adhesion to endothelial cells, generation of ROS and so on

Rumi et al

B12 deficiency becomes increasingly common with age due to atrophic gastritis, reduced intrinsic factor production, and polypharmacy

men with HH have a 12-fold increased lifetime risk of primary liver cancer of 7.2% compared with 0.6% in those without HFE mutations

doi: 10.1093/jac/39.1.5