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Nociplastic pain involves central sensitization without structural damage, driven by glial activation, dysregulated descending control, and stressaxis dysfunction

[DOI] [PubMed] [Google Scholar] 243.Inoue H et al

This is achieved by enhancing the activity of endogenous antioxidant enzymes (SOD, CAT, GR, GPx, and GSH) or by inhibiting oxidative stress-induced damage in the reproductive system

Developing senolytics with high selectivity and efficacy in targeting senescent cells while minimizing off-target effects on healthy cells remains an ongoing challenge

Currently, it is evident that health professionals should deal with the overall health status of COVID-19 survivors