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The headache phase follows the prodromal or aura stages of a migraine, marked by the activation and sensitization of the trigeminovascular system (TVS) and brainstem, leading to disrupted sensory processing and various neurological symptoms indicative of altered brain excitability (29)

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In some embodiments, the otic formulation or composition comprises about 0.01% to about 1% by weight of the viscosity modulating agent(s)