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Future research using transgenic animal models will include: conditional, organ-specific knockdown of Sestrin 2 and attempts to link Sestrin 2 levels (inpatient biopsy samples) to disease progression will help us to identify biochemical pathways regulated by Sestrin 2 in specific diseases

11(3): e0149394

However, many proposed dual-action agents, including phenolics and alkaloids, exhibit inconsistent potency, low bioavailability, or narrow mechanistic range, limiting their translational potential (Daley and Cordell, 2021

This reveals an additional layer of complexity in the regulation of BCAA metabolism and its connection to cardiovascular protection

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