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NF-B, nuclear factor B

this can be caused by poor lifestyle choices, stress, or aging

Tracking neurotransmitter-related markers and hormones, such as GHRH, somatostatin surrogates, cortisol, and prolactin, helps track hypothalamic response

It plays a key role in the hypothalamus, a part of the brain in research models that helps control body timing, including sleep and daily rhythm patterns

Furthermore, the presence of certain biomarkers, such as ACAT2 expression, cholesteryl-ester burden, and SREBF2-activity signatures, may assist in the identification of patients who are most likely to benefit from these strategies, thereby serving as pharmacodynamic readouts during treatment