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In rats subjected to polymicrobial sepsis by CLP, the increased expression of iNOS, cyclooxygenase-2 (COX-2), and TNF- mRNAs and decreased reduced glutathione were suppressed in the liver by vitamin C treatment intravenously immediately after the CLP procedure (Schorah et al., 1996

These contraindications are based on safety concerns identified in animal studies or lack of adequate human safety data in these populations

[PMC free article: PMC6005447] [PubMed: 29712723] 284

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Recognizing these patterns is essential for moving toward more individualized supplementation strategies in both research and clinical practice