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Limitations and Challenges in Interpreting Findings from Clinical, In Vitro and In Silico Studies The primary impediment to utilizing hesperidin as a compound against SARS-CoV-2 is the disparity between the concentrations of hesperidin utilized in laboratory experiments in vitro and clinical studies (typically three times daily 500 mg per os) and the amounts that can be obtained from consuming citrus fruits

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Concerning the first criterion, the percentage identity between members of a given class is usually above 50%, whereas it is usually below 20% between classes

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