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53, 54 One study of mitochondrial dysfunction in the autism brain found decreased protein levels of multiple ETC complexes in the cerebellum, frontal and temporal cortex

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Consistent supplementation may help improve energy levels, cognitive clarity, and natural liver detoxification pathways

Meanwhile, researchers discovered Mitochondria-targeted antioxidants (MTAXs) that can improve mitochondrial functions and antioxidant activity through the modulation of mitochondrial signaling pathways, including peroxisome proliferator-activated receptor (PPAR)-coactivator 1 (PGC-1), dynamin-related protein 1 (Drp1), mitochondrial fission protein 1 (Fis1), and Silent mating type information regulation 2 homolog 1 (SIRT-1), showing neuroprotective effects in HD

For example, solid lipid nanoparticles are composed of biocompatible and biodegradable materials that can deliver polyphenols directly to neuronal cells, thereby reducing systemic side effects and increasing the concentration of these compounds in the brain [268]