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Our research indicates that the greatest improvement in subjective sleep quality can be expected if overall sleep efficiency is improved, while other intervention targets (e.g

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However, in the entire WD population (regardless of adherence, clinical symptoms, initial stage of disease or type of treatment), studies generally show that mortality rates in patients with WD (56.1%) are higher than healthy controls 1315

(4) Despite the advent of numerous nano-formulations based on disulfiram, the primary obstacles to their clinical application include safety concerns pertaining to the use of nano-drugs in preclinical and clinical studies, which have resulted in an approval rate of less than 10 %, and mounting concerns about biosafety (Wang et al., 2024)