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Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

They are not held to the same purity, potency, or safety standards that apply to medications intended for human administration

In cholesterol metabolism, H 2 O 2 /O/OH/LOOH inhibit cholesterol synthesis by oxidatively modifying HMG-CoA reductase [195, 196]