do glutathione levels fluctuate throughout the day Post-irradiation fluctuation in reduced glutathione. GSH found main function of glutathione Glutathione,

Further, MTX increased the expression of PERK (Figure 6B), GRP78 (Figure 6C), ATF4 (Figure 6D), and CHOP-10 (Figure 6E) in the liver compared to CTRL, indicating that ER stress is implicated in MTX-induced hepatotoxicity

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Three distinct SOD subtypes, namely, Cu/ZnSOD (encoded by the SOD1 gene), MnSOD (encoded by the SOD2 gene), and extracellular SOD (ecSOD, encoded by the SOD3 gene), have been identified and characterized in mammals [30]

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