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For example, phenytoin, carbamazepine, and phenobarbital (or primidone) can double the clearance of valproate

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It may also lead toincreased risk of atherosclerosis by increasing blood levels of trimethylamine-N-oxide (TMAO) over time

Neutralizing antibodies are one way to block the cascade reaction of a cytokine storm by blocking the active sites of these cytokines.
