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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Leite B., Gomes F., Teixeira P., Souza C., Pizzolitto E., Oliveira R

Markley J

Niacinamide Improves texture and reduces redness

Immunofluorescence in vitro To detect the change of HIF-1 expression, A375 cells were seeded at a density of 5 10 3 cells/well for 24 h under hypoxic (1% O 2 , 5% CO 2 , and 94% N 2 ) and normoxic (21% O 2 , 5% CO 2 , and 74% N 2 ) conditions, respectively, and then incubated with blank medium, 5-ALA, CCPA, and CCPCA NPs for another 24 h

Antioxidant enzymes such as superoxide dismutase 1 (SOD1), and glucose6phosphate dehydrogenase (G6PD) decrease from HMRD-induced oxidative stress (OxS) and protein degradation 50,51