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Specifically, overexpressed GPX3 induced mitochondrial dysfunction and cytoplasmic transfer of Cyto-C through up-regulation of BAX and down-regulation of Bcl-2, and ultimately induced mitochondria-dependent apoptosis via the caspase 9-caspase 3 cascade, and then cooperated with the blocking effect of GPX3 on G0/G1 phase to attenuate the proliferation activity of prostate cells

Activation of apoptosis signalling pathways by reactive oxygen species

Morris G, Berk M, Carvalho AF et al (2018) Why should neuroscientists worry about iron

doi: 10.1039/D3FO05708A

True management of these complex conditions requires a comprehensive strategy that includes aggressive pacing, nervous system regulation, symptom tracking, and targeted nutritional support
