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Importantly, autophagy is another key contributor to cancer stem cells promoting their longevity as quiescent cells (Vera-Ramirez et al., 2018) and its downregulation is associated with cancer stem cell reactivation ( Modulation of p53 Stability and Activity by TRIMs The tumor suppressor protein p53 promotes genomic stability and can induce cell cycle arrest and apoptosis resulting from extensive cellular DNA damage

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Nonetheless, the forced overexpression of GPx1 has been shown to suppress cellular proliferation and migration of pancreatic cancer cells [133, 134], suggesting that GPx1 is a tumor suppressor in some cancers

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In the case of intramuscular injections, where the vector can drain into the lymphatic system and provoke an immune response, it is important to optimize the dosage and volume of the injection in order to minimize leakage of the vector into the systemic circulation

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