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Hayes RB

This leads to neurodegenerative changes, most prominently in hippocampus, observed in depression

Suboptimal sperm methylation in terms of quality and quantity (CpG island regions restricted to retained histones) has a negative impact on human embryo blastocyst development [9] Approximately 1015% of histones are retained, but these are not randomly located: they bind to the active part/coding area of DNA and so play an important role in embryonic development [6,9]

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Specifically, it has been shown that 100 mg LA/kg body weight/day for 2 weeks i.p