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In addition, next-generation intranasal drug delivery devices, including bidirectional nasal sprays and the precision olfactory delivery (POD) technology, have further optimised drug deposition efficiency and enhanced therapeutic outcomes

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Disrupting the N-glycan interactions affect GluK3 gating properties To test whether these glycan interactions could affect gating properties of GluK3 receptors, we systematically mutated N-glycan sites

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Since this ratio of conformers (95:5) represents a system at equilibrium, we can actually use it to calculate the difference in energy of these two conformers using the following equation: For a 50:50 mixture ( K = 1) the energy difference G would be zero