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The IMQ-induced psoriasis mouse model was developed according to previously established methods

Such radicals in turn attack neighboring PUFAs, generating additional radicals which propagate free radical reactions and the degeneration of membrane lipids (560, 1055), causing membrane permeability and fluidity changes with significant biological consequences (1075)

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Because PGE 2 is the prostanoid most associated with inflammatory responses, the formation of PGE 2 at inflammatory sites is often considered an indicator of local COX activity, and suppression of PGE 2 is an indicator of a decreased inflammatory process

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