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Following each experiment, the cells were washed once with PBS (LPS solution CBP007B) and fixed with 10% formalin solution (Sigma HT501128-4L) for 10 min at room temperature

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Ligand exchange with solvent water occurs via an associative mechanism (Datta and Raymond, 2009), and an initial equilibrium is present with a fast water exchange rate (Eq

Metabolomics data are provided in the Supplementary Tables 3, 4

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