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Oral Phosphodiesterase-5 Inhibitors (PDE5I) Medications Oral medication for ED refers most of the time to PDE5 inhibitors, which remain the first-line treatment for ED and include: Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Their primary mechanism of action involves the inhibition of the enzyme phosphodiesterase type 5 (PDE-5), which is found in the smooth muscle cells of the penis

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148,149 On the other hand, there is evidence that CCK may play a key part in longer-term energy regulation by synergizing with the actions of leptin

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Soares MO, Dumville JC, Ades AE, Welton NJ (2014) Treatment comparisons for decision making: facing the problems of sparse and few data