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Text Box 8 includes some of the salient points regarding the relations among B12, folate, and megaloblastic anemia (39)

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Symptoms and Consequences of Iron Deficiency in Pregnant Women Iron deficiency is a common issue among pregnant women, affecting one in two expectant mothers, with anemia occurring in over 25% of cases [12]

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Thus, through high consumption of NAD + , CD38 also indirectly impacts the activity of other NAD + -consuming enzymes such as sirtuins 52

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