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Most of the cases have affected adult blacks (90%

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Exposure to GBB results in the upregulation of a specific microbial gene cluster, gbu (GBB utilizing), which is responsible for the conversion of GBB to TMAand more abundant in people who eat red meat

It is induced by mutations in the gene encoding 3-hydroxysterol- 7 -reductase (DHCR7), the enzyme catalyzing cholesterol formation by 7-dehydrocholesterol reduction
