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Biochem Biophys Res Comm

doi: 10.1016/j.toxlet.2012.11.020

AVONEX was approved for relapsing forms of MS in 1996

However, when accounting for within-patient clustering using a MANCOVA with patient as a fixed effect, the multivariate omnibus test was significant, and univariate effects remained significant for insomnia and end-of-dose crash, but not for poor appetite or return of symptoms

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