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While the exact mechanisms remain unclear, two primary theories have been proposed: 1) an immune-mediated systemic reaction causing vasoconstriction and a prothrombotic state leading to ischemia and subsequent stroke

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Concurrent administration of the two peptides is thus believed to have more potent healing effects, with research suggesting a synergistic effect to accelerate the migration of fibroblasts and immune system cells to sites of injury [8, 9, 11]

Report of two cases and review of the literature

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