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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

Yin Yang 1 (YY1), a highly conserved C2H2 zinc finger nuclear transcription factor that is overexpressed in M2 macrophages within PCa tissues, plays a crucial role in this process (Cho et al., 2018)

There are eight isozymes of GPXs (GPX 18) that have been identified in humans in different tissues, among these five are selenoproteins (GPXs 14 and GPX6) that play an important role in defense against oxidative stress