elegans glutathione cytosol Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis Changes in ferrous iron and

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The method is based on the oxidation of GSH and the reduction of tBuOOH to its corresponding hydroxide by GPX, coupled to GSSG production by glutathione reductase (GR) activity paired to NADPH consumption monitored at 340 nm in a Beckman DU-640 Spectrophotometer

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While FIN56 acts solely as a ferroptosis inducer, CIL56 also activates a non-ferroptotic mechanism at higher concentrations and is dependent on ACC1 (acetyl-CoA carboxylase alpha) [32]

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