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Description
Increased activity of NADPH oxidase reduces the concentration of free NADPH that is needed to reduce GSSG to GSH

10.1038/nprot.2008.73 28

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Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant