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* The Difference Median column refers to the median of the observed differences between the values of the subjects biomarkers at a given date and the baseline (e.g., the median of the observed differences between the platelet count on days D14 and D01)

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Epigenetic mechanisms are chemical modifications in the DNA or histones which alter chromatin status and gene transcription levels without changes in the nucleotide DNA sequence

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10.1210/jcem.86.5.7463 J

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