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[Abstract]2024 Jun 28:2024.06.28.601172

Studies have shown that natural bioactive compounds from TCM (e.g., berberine, curcumin) contribute to synergistic anti-inflammatory and antioxidant effects, as well as enhanced drug-targeted delivery, while TCM formulations (e.g., Gegen Qinlian Decoction, Xilei San) exert holistic multi-target regulation by inhibiting key inflammatory pathways such as nuclear factor-kappa B (NF-B) and mitogen-activated protein kinase (MAPK), modulating gut microbiota composition, and restoring mucosal barrier function

PGE 2 is the predominant eicosanoid released from the endothelial cells of small blood vessels and a key mediator of both peripheral and central pain sensitization

TMC-coated AuNPs (AuNPs-TMC) were prepared by adding 1 ml of prepared TMC solution (2 mg/ml) in deionized water to AuNPs while continuing the stirring process for another 15 min