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Hybrid lipid/polymer nanoparticles to tackle the cystic fibrosis mucus barrier in siRNA delivery to the lungs: does PEGylation make the difference

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The main drawback to using RNA as a therapy is naked RNA cannot simply be injected as it is immunogenic, easily susceptible to enzymatic degradation, and is not taken up by cells

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The battery overheats, swells, or shows physical damage like puffing or casing rupture

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The frequency of auditory adverse reactions was increased among pediatric patients who received deferasirox doses greater than 25 mg/kg/day when serum ferritin was less than 1,000 mcg/L [see Warnings and Precautions (5.6)]

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Values are mean SEM

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