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A prolonged deficiency leads, in the worst case, to lethal anemia, irreparable nerve damage, severe paralysis, chronic pain, severe mental and psychological symptoms and a complete lack of energy

[1] The NHS advises that taking up to 2mg (2000 micrograms) per day of vitamin B12 supplements is unlikely to cause harm

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There were possibly significant increases in arginine and glycine, with both changing from slightly below the average neurotypical value to slightly above

[DOI] [PubMed] [Google Scholar] 127.Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, et al