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Although dysfunction of the valves in leg veins is the typical cause of increased venous blood pressure, other factors can also contribute, including obstruction of the veins (eg, by blood clots) and decreased contraction of calf muscles (eg, due to leg immobility)

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High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE(/) mice