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Description
Current research suggests that in macrophagesespecially under conditions of impaired phagolysosome function, altered heme transport activity, and oxidative stressHO-1 may shift from a cytoprotective to a cytotoxic role
Mechanistically, SYVN1 binds to HMGB1, promoting its ubiquitination and degradation and alleviating SCIRI in rats by downregulating HMGB1 and activating the Nrf2/HO-1 pathway

Acetylcholine balances brain signals and regulates how neurons fire

KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer

All studies are restricted to laboratory and research environments
