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Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

Morphologically, ferroptosis is mostly characterized by smaller mitochondria, increased membrane density, reduced or absent mitochondrial ridges, and normal cell size but a lack of chromatin cohesion (Sun et al., 2023)

Notably, these two markers did not co-localize significantly, indicating that the up-regulation of COX2 occurred in cells other than HSCs (Pearsons_Rr = 0.197)

Under conditions of normal metabolism, mitochondrial LDH slowly reduces pyruvate to lactate which allows for electrons in NADH to be transferred to pyruvate, forming lactate

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