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Kadioglu, A., Tefekli, A., Koksal, T., Usta, M
[DOI] [PubMed] [Google Scholar] 14.Coluzzi F., Rullo L., Scerpa M.S., Losapio L.M., Rocco M., Billeci D., Candeletti S., Romualdi P
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doi: 10.1007/s11011-018-0219-1
In an endothelium-independent way, CGRP, due to its receptors, causes adenylate cyclase activation and cAMP increase, which activates protein kinase A (PKA), and this, in turn, phosphorylates ATP-dependent K+ channels, which leads to Ca 2+ sequestration mechanisms and causes smooth muscle relaxation
