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this could be due to a lack of understanding regarding its mechanisms, as well as the fact that over the past two decades, only a handful of studies have researched the peptide (many from the same laboratory or group)

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239 In addition, while wild-type CRYAB exhibited intact chaperone activity by inhibiting dithiothreitol (DTT)-induced aggregation of insulin, the D140N variant promoted insulin aggregation at room temperature

Currently, there is no established mechanism for how hepatotoxicity develops