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In patients with hyperprolinemia, proline accumulation can cause a decrease in ATPase activity, which further leads to mitochondrial stress and elevated lactate levels, and can also decrease glutamate uptake [17]

Eight-week-old male C57BL/6 mice ( n = 42) were purchased from the National Laboratory Animal Center and housed in the laboratory animal center of Taipei Medical University (Taipei City, Taiwan)

Although long-term endurance training and the late recovery phase after acute bouts tend to promote M2-like macrophage polarization, the early phase following acute exercise is dominated by the mobilization of pro-inflammatory monocytes and an increase in M1-like macrophage infiltration, particularly in skeletal muscle tissues (3941)

Infection Though rare, there is a small risk of infection at the injection site

[DOI] [Google Scholar] 19.Kumar S., Rao R., Kumar A., Mahant S., Nanda S