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For further optimization, the central gene fragment of PapRS#0, flanked by the two Bsa I restriction sites, was subjected to error-prone PCR using the GeneMorph II random mutagenesis kit (Agilent), adjusting a mutagenesis frequency of 4 nucleotide exchanges

Ferroptosis, an iron-dependent form of cell death characterized by excessive lipid peroxidation, is distinct from apoptosis and necrosis

Kramer, M

Low glutathione allows peroxidative damage to proceed unchecked, leading to neuronal vulnerability