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Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial

We focused on sperm quality (count, motility, and morphology), hormone levels (FSH, LH, testosterone), oxidative stress markers (MDA, GSH, NO, CAT, SOD), expression of steroidogenesis-related genes (StAR, 3-HSD, Cyp17a, Aromatase), and histopathological analysis of the testes