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Pediatrics 110 , 377385 (2002)

We observed a relatively late appearance of TMAO, which confirms that carnitine is first degraded to TMA by anaerobic microbes, which are located in the lower part of the gastrointestinal system

Further, since oral L-carnitine supplementation has been reported to have some beneficial effects on the physical capacity in HD patients [20], although ours was a cross-sectional study and, therefore, did not elucidate the causal relationships between low carnitine and exercise inactivity, decreased carnitine levels may predict the exercise inactivity in HD patients

For analyses with a single effect size per study, standard random-effects models (metafor package, R) were used, providing SMDs, 95% CIs, and heterogeneity indices (, I, Q)

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